Electronic resources are vital for achieving the cardinal goals of polytechnics. However, it is unclear if the lecturers have information literacy abilities and computer self-efficacy for using electronic resources. Therefore, the study investigated the influence of information literacy skills and computer self-efficacy on the use of electronic resources by academic staff in Federal Polytechnic, Ede. The descriptive survey design was adopted for the study. Data were analyzed using descriptive and inferential statistics. Of the 186 respondents, findings revealed that the levels of computer self-efficacy, information literacy skills and electronic resources use of the lecturers were high. A positive and significant relationship was found between computer self-efficacy and electronic resource use (r=0.525, p<0.05), information literacy skills and electronic resource use (r=0.442, p<0.05). Computer self-efficacy and information literacy skills had a positive joint influence on the use of electronic resources by academic staff in Federal Polytechnic, Ede. The study, therefore, concludes that information literacy and computer self-efficacy can enhance the use of electronic resources for the good of the academic activities and research endeavours of the lecturers, which would eventually translate to better service delivery not only to the Federal Polytechnic, Ede, but also to the generality of the higher institutions in Nigeria.