Cataloguing and classification provide means of having easy access to, and retrieval of information. This study investigates perception of librarians on the impact of cataloguing and classification on the use of information resources of academic libraries in Kwara State. It adopts a descriptive survey, as it aims to accurately and systematically describe a population, situation or phenomenon understudying. Purposive sampling technique was used to select 53 librarians across 13 academic libraries in Kwara State. Questionnaire was used to collect data from the respondents and data collected was analyzed by using the Statistical Package for Social Science (SPSS, 22ndedition). The result of the findings reveals that users consult library catalogue before accessing library and information resources and that cataloguing and classification as a tool for providing access to information resources promotes library usage, while the challenges associated with that inadequate knowledge of how information resources are arranged, improper shelving of information resources, lack of awareness of cataloguing and classification in the library among others. The study recommends, among others, that professional librarians should be deployed to the readers’ service section to help in properly arranging library and information resources, and also ensure that the library move with latest trends to electronic cataloguing system in the library.